Inositol Trispyrophosphate (ITPP) is a synthetic compound derived from inositol, a naturally occurring sugar alcohol. It was initially developed as a potential therapeutic agent for conditions involving inadequate oxygen supply to tissues, such as cardiovascular diseases. ITPP is believed to enhance oxygenation by facilitating the release of oxygen from red blood cells (RBCs), thus potentially improving endurance and performance.
For that reason, it is often used by endurance athletes to maximize stamina and cardiovascular output. In this article, we will explore the mechanism of action of ITPP, its pros and cons, as well as how to use it effectively.
How does ITPP work?
ITPP is thought to work by binding to hemoglobin, the protein responsible for carrying oxygen in RBCs. This binding is believed to alter the affinity of hemoglobin for oxygen, making it easier for oxygen to be released from RBCs and delivered to tissues. By improving oxygen availability, ITPP can enhance endurance and stamina.
Benefits of ITPP
The benefits of ITPP are the following:
- Enhanced Oxygen Delivery: This increased oxygen availability may result in enhanced endurance and performance during physical activities that require aerobic metabolism.
- Increased Stamina: Improved oxygenation of tissues may contribute to increased stamina and prolonged exercise capacity, allowing individuals to perform at a higher intensity for longer durations. Some studies have shown that it can increase endurance by up to 57%
- Tissue Repair and Recovery: Due to the increased tissue oxygenation, it would not be a far stretch to suggest that ITPP may have regenerative properties, facilitating tissue repair and recovery from injuries.
- Nootropics benefits: Many ITPP users report having more brain power and feeling very clear-headed and alert. This makes perfect sense when we consider that ITPP also improve oxygen delivery to the brain.
From a bodybuilding perspective, ITPP can help users lift slightly heavier for more reps, as well as train harder and burn more fat by increasing endurance (greater ability to exercise at a high-level for extended period of time inevitably leads to more muscle stimulation when lifting and more calories burned when doing cardio).
Some studies also suggest that it may help combat certain types of cancer, cardiovascular diseases and other diseases that stem from a lack of proper oxygenation.
Side-effects of ITPP
Believe it or not, most ITPP users report no side-effects whatsoever. This is because unlike other endurance-boosting agents, ITPP makes RBCs more effective at delivering oxygen INSTEAD of increasing the total concentration of RBCs (which is what causes high blood pressure and other cardiovascular issues).
How to use ITPP
The recommended ITPP dose is 300 to 500mg taken every 3 days. It can be used orally, and there is no established maximum cycle length, although I would personally only use it as needed during periods of intense exercise or in preparation for a specific event that requires peak performance.
None of my trusted sources currently sells it, but it’s not hard to find sellers online by googling “buy ITPP in the (country name)”
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